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“Der Granatapfel – wirkungsvolle Gesundheitsfrucht für Prostata, Herz, Gehirn und Immunsystem“


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Afaq F, Malik A, Syed D, Maes D, Matsui MS, Mukhtar H (2005): Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappaB in normal human epidermal keratinocytes paragraph sign. Photochem Photobiol;81:38–45.

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Davidson MH, Maki KC, Dicklin MR, Feinstein SB, Witchger M, Bell M, µguire DK, Provost JC, Liker H, Aviram M (2009): Effects of consumption of pomegranate juice on carotid intima-media thickness in men and woman at moderate risk for coronary heart disease. Am J Cardiol;104:936–942.

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Fuhrman B, Volkova N, Aviram M (2006): Postprandial serum triacylglycerols and oxidative stress in mice after consumption of fish oil, soy oil or olive oil: possible role for paraoxonase-1 triacylglycerol lipase-like activity. Nutrition; 22(9): 922-930.

Fuhrman B, Volkova N, Aviram M (2010): Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: studies in vitro and in diabetic patients. Nutrition; 26(4): 359-366.

Gonzalez-Ortiz M, Martinez-Abundis E, Espinel-Bermudez MC, Perez-Rubio KG. Effect of pomegranate juice on insulin secretion and sensitivity in patients with obesity. Ann Nutr Metab. 2011;58(3):220-3.

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Gugliucci A. Beyond the antioxidant properties: pomegranate juice polyphenols increase hepatocyte paraoxonase 1 secretion. Atherosclerosis. 2010 Jan;208(1):28-9.

Guo C, Wei J, Yang J, Xu J, Pang W, Jiang Y (2008): Pomegranate juice is potentially better than apple juice in improving antioxidant function in elderly subjects. Nutr Res; 28(2): 72-77.

Hadi SM, Bhat SH, Azmi AS, Hanif S, Shamim U, Ullah MF (2007): Oxidative breakage of cellular DNA by plant polyphenols: a putative mechanism for anticancer properties. Semin Cancer Biol;17:370–376.

Hashemi M, Kelishadi R, Hashemipour M, Zakerameli A, Khavarian N, Ghatrehsamani S, Poursafa P (2010): Acute and long-term effects of grape and pomegranate juice consumption on vascular reactivity in paediatric metabolic syndrome. Cardiol Young; 20(1): 73-77.

Hassanpour Fard M, Ghule AE, Bodhankar SL, Dikshit M. Cardioprotective effect of whole fruit extract of pomegranate on doxorubicin-induced toxicity in rat. Pharm Biol. 2011 Apr;49(4):377-82.

Hassing LB, Johansson B, Nilsson SE, Berg S, Pedersen NL, Gatz M, McClearn G. Diabetes mellitus is a risk factor for vascular dementia, but not for Alzheimer’s disease: a population-based study of the oldest old. Int Psychogeriatr 2002;14:239-48.

Hidaka M, Okumura M, Fujita K, Ogikubo T, Yamasaki K, Iwakiri T, Setoguchi N, Arimori K (2005): Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos;33:644–648.

Hong MY, Seeram NP, Heber D (2008): Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. J Nutr Biochem;19:848–855.

Hosseini B, Saedisomeolia A, Wood LG, Yaseri M, Tavasoli S (2016): Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: A randomized controlled clinical trial. Complement Ther Clin Pract; 22: 44-50.

Huang TH, Yang Q, Harada M, Li GQ, Yamahara J, Roufogalis BD, Li Y (2005): Pomegranate flower extract diminishes cardiac fibrosis in Zucker diabetic fatty rats: modulation of cardiac endothelin-1 and nuclear factor-kappaB pathways. J Cardiovasc Pharmacol;46:856–862.

Ignarro LJ, Byrns RE, Sumi D, de Nigris F, Napoli C (2006): Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. Nitric Oxide;15:93–102.

Irace C, Cortese C, Fiaschi E, et al. The influence of PON1 192 polymorphism on endothelial function in diabetic subjects with or without hypertension. Hypertens Res. 2008 Mar;31(3):507-13.

Jacob LM (2007): Granatapfel: Prävention und adjuvante Ernährungstherapie bei Krebserkrankungen. Erfahrungsheilkunde;56:464–473.

Jacob LM (2007): Granatapfel: Prävention und adjuvante Ernährungstherapie bei Herz-Kreislauf-Erkrankungen. Erfahrungsheilkunde;56:602–610.

Jacob LM (2008): Granatapfel als Zellregulator. Komplement Integr Med;1:16–20.

Jacob LM, Klippel KF (2008): Granatapfelpolyphenole gegen Prostatakarzinom. Dtsch Z Onkol; 40:112–119.

Jarvis S, Li C, Bogle RG (2010): Possible interaction between pomegranate juice and warfarin. Emerg Med J. Jan;27(1):74-5.

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Kawaii S, Lansky EP (2004): Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells. J Med Food;7:13–18.

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Keating NL, O'Malley AJ, Smith MR (2006): Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. J Clin Oncol. Sep 20;24(27):4448-56.

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Khan N, Hadi N, Afaq F, Syed DN, Kweon MH, Mukhtar H (2007): Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice. Carcinogenesis;28:163–173.

Khateeb J, Gantman A, Kreitenberg AJ, Aviram M, Fuhrman B. Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-gamma pathway. Atherosclerosis. 2010 Jan;208(1):119-25.

Kim DO, Lee KW, Lee HL, Lee CY (2002): Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. J Agric Food Chem;50:3713–3717.

Kim H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH (2006): Inhibitory effects of fruit juices on CYP3A activity. Drug Metab Dispos;34:521–523.

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Kim ND, Mehta R, Yu W, Neeman I, Livney T, Amichay A, Poirier D, Nicholls P, Kirby A, Jiang W, Mansel R, Ramachandran C, Rabi T, Kaplan B, Lansky E (2002): Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat;71:203–217.

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Koren-Gluzer M, Aviram M, Meilin E, Hayek T. The antioxidant HDL-associated paraoxonase-1 (PON1) attenuates diabetes development and stimulates beta-cell insulin release. Atherosclerosis. 2011 Dec;219(2):510-518.

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Lansky EP, Harrison G, Froom P, Jiang WG (2005): Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel. Invest New Drugs;23:121–122.

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