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“Der Granatapfel – wirkungsvolle Gesundheitsfrucht für Prostata, Herz, Gehirn und Immunsystem“


Adams LS, Zhang Y, Seeram NP, Heber D, Chen S (2010): Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev Res (Phila Pa);3:108–113.

Afaq F, Malik A, Syed D, Maes D, Matsui MS, Mukhtar H (2005): Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappaB in normal human epidermal keratinocytes paragraph sign. Photochem Photobiol;81:38–45.

Afaq F, Saleem M, Krueger CG, Reed JD, Mukhtar H (2005): Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Int J Cancer;113:423–433.

Ahmed S, Rahman A, Saleem M, Athar M, Sultana S (1999): Ellagic acid ameliorates nickel induced biochemical alterations: diminution of oxidative stress. Hum Exp Toxicol;18:691–698.

Ahmed S, Wang N, Hafeez BB, Cheruvu VK, Haqqi TM (2005): Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro. J Nutr;135:2096–2102.

Albrecht M, Jiang W, Kumi-Diaka J, Lansky EP, Gommersall LM, Patel A, Mansel RE, Neeman I, Geldof AA, Campbell MJ (2004): Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells. J Med Food;7:274–283.

Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis. 2001 Sep;158(1):195-8.

Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, Volkova N, Presser D, Attias J, Liker H, Hayek T (2004): Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr;23:423–433.

Azmi AS, Bhat SH, Hanif S, Hadi SM (2006): Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties. FEBS Lett;580:533–538.

Beer TM, Lalani AS, Lee S, Mori M, Eilers KM, Curd JG, Henner WD, Ryan CW, Venner P, Ruether JD, Chi KN (2008); ASCENT Investigators: C-reactive protein as a prognostic marker for men with androgen-independent prostate cancer: results from the ASCENT trial. Cancer;112:2377–2383.

Birnie R, Bryce SD, Roome C, Dussupt V, Droop A, Lang SH, Berry PA, Hyde CF, Lewis JL, Stower MJ, Maitland NJ, Collins AT (2008): Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions. Genome Biol;9:R83.

Brewer GJ, Dick RD, Grover DK, LeClaire V, Tseng M, Wicha M, Pienta K, Redman BG, Jahan T, Sondak VK, Strawderman M, LeCarpentier G, Merajver SD (2000): Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study. Clin Cancer Res;6:1–10.

Cakatay U, Kayali R, Uzun H. Relation of plasma protein oxidation parameters and paraoxonase activity in the ageing population. Clin Exp Med. 2008 Mar;8(1):51-7.

Cano-Lamadrid M, Marhuenda-Egea FC, Hernández F, Rosas-Burgos EC, Burgos-Hernández A, Carbonell-Barrachina AA (2016): Biological Activity of Conventional and Organic Pomegranate Juices: Antioxidant and Antimutagenic Potential. Plant Foods Hum Nutr; [Epub ahead of print].

Carducci MA, Paller CJ, Wozniak P, Sieber P, Greengold R, Stockton B, Hertzman B, Roper R, Liker H, Ye X (2011): A phase II study of pomegranate extract for men with rising prostate-specific antigen following primary therapy. J Clin Oncol; 29 (suppl 7; abstr 11).

Cavalieri E, Frenkel K, Liehr JG, Rogan E, Roy D (2008): Estrogens as endogenous genotoxic agents-DNA-adducts and mutations. J Natl Cancer Inst Monogr;27:75–93.

Cerdá B, Espín JC, Parra S, Martínez P, Tomás-Barberán FA (2004): The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans. Eur J Nutr;43:205–220.

Charles KA, Rivory LP, Stockler MR, Beale P, Beith J, Boyer M, Clarke SJ: Predicting the toxicity of weekly docetaxel in advanced cancer. Clin Pharmacokinet 2006;45:611–622.

Chen D, Peng F, Cui QC, Daniel KG, Orlu S, Liu J, Dou QP (2005): Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis. Front Biosci;10:2932–2939.

Cui Y, Watson DJ, Girman CJ, et al. Effects of increasing high-density lipoprotein cholesterol and decreasing low-density lipoprotein cholesterol on the incidence of first acute coronary events (from the Air Force/Texas Coronary Atherosclerosis Prevention Study). Am J Cardiol. 2009 Sep 15;104(6):829-34.

Davidson MH, Maki KC, Dicklin MR, Feinstein SB, Witchger M, Bell M, µguire DK, Provost JC, Liker H, Aviram M (2009): Effects of consumption of pomegranate juice on carotid intima-media thickness in men and woman at moderate risk for coronary heart disease. Am J Cardiol;104:936–942.

de la Monte SM, Wands JR (2008): Alzheimer's Disease Is Type 3 Diabetes–Evidence Reviewed. J Diabetes Sci Technol. 2008 November; 2(6): 1101–1113.

de la Monte SM. Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease. Drugs. 2012 Jan 1;72(1):49-66.

de Nigris F, Williams-Ignarro S, Botti C, Sica V, Ignarro LJ, Napoli C. Pomegranate juice reduces oxidized low-density lipoprotein downregulation of endothelial nitric oxide synthase in human coronary endothelial cells. Nitric Oxide. 2006 Nov;15(3):259-63.

De Nunzio C, Aronson W, Freedland SJ, Giovannucci E, Parsons JK (2012): The correlation between metabolic syndrome and prostatic diseases. Eur Urol.; 61(3):560-70.

Esmaillzadeh A, Tahbaz F, Gaieni I, Alavi-Majd H, Azadbakht L (2006): Cholesterol-lowering effect of concentrated pomegranate juice consumption in type II diabetic patients with hyperlipidemia. Int J Vitam Nutr Res;76:147–151.

Falsaperla M, Morgia G, Tartarone A, Ardito R, Romano G (2005): Support ellagic acid therapy in patients with hormone refractory prostate cancer (HRPC) on standard chemotherapy using vinorelbine and estramustine phosphate. Eur Urol; 47:449–454.

Faria A, Monteiro R, Azevedo I, Calhau C (2007): Pomegranate juice effects on cytochrome P450s expression: in vivo studies. J Med Food;10:643–649.

Farkas D, Oleson LE, Zhao Y, Harmatz JS, Zinny MA, Court MH, Greenblatt DJ (2007): Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450–3A activity: comparison with grapefruit juice. J Clin Pharmacol;47:286–294.

Farrell GC, van Rooyen D, Gan L, Chitturi S. NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. Gut Liver. 2012 Apr;6(2):149-71. Epub 2012 Apr 17.

Fenercioglu AK, Saler T, Genc E, Sabuncu H, Altuntas Y (2010): The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications. J Endocrinol Invest; 33(2): 118-124.

Fischer-Zorn M, Ara V (2007): Granatapfelsaft – Chemische Zusammensetzung und mögliche Verfälschungen. Flüssiges Obst 8/2007:386–393.

Forest CP, Padma-Nathan H, Liker HR (2007): Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study. Int J Impot Res;19:564–567.

Fuhrman B, Volkova N, Aviram M (2005): Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages. J Nutr Biochem;16:570–576.

Fuhrman B, Volkova N, Aviram M (2006): Postprandial serum triacylglycerols and oxidative stress in mice after consumption of fish oil, soy oil or olive oil: possible role for paraoxonase-1 triacylglycerol lipase-like activity. Nutrition; 22(9): 922-930.

Fuhrman B, Volkova N, Aviram M (2010): Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: studies in vitro and in diabetic patients. Nutrition; 26(4): 359-366.

Gonzalez-Ortiz M, Martinez-Abundis E, Espinel-Bermudez MC, Perez-Rubio KG. Effect of pomegranate juice on insulin secretion and sensitivity in patients with obesity. Ann Nutr Metab. 2011;58(3):220-3.

Griffin JD (2001): Leukemia stem cells and constitutive activation of NF-kappaB. Blood;98:2291.

Gugliucci A. Beyond the antioxidant properties: pomegranate juice polyphenols increase hepatocyte paraoxonase 1 secretion. Atherosclerosis. 2010 Jan;208(1):28-9.

Guo C, Wei J, Yang J, Xu J, Pang W, Jiang Y (2008): Pomegranate juice is potentially better than apple juice in improving antioxidant function in elderly subjects. Nutr Res; 28(2): 72-77.

Hadi SM, Bhat SH, Azmi AS, Hanif S, Shamim U, Ullah MF (2007): Oxidative breakage of cellular DNA by plant polyphenols: a putative mechanism for anticancer properties. Semin Cancer Biol;17:370–376.

Hashemi M, Kelishadi R, Hashemipour M, Zakerameli A, Khavarian N, Ghatrehsamani S, Poursafa P (2010): Acute and long-term effects of grape and pomegranate juice consumption on vascular reactivity in paediatric metabolic syndrome. Cardiol Young; 20(1): 73-77.

Hassanpour Fard M, Ghule AE, Bodhankar SL, Dikshit M. Cardioprotective effect of whole fruit extract of pomegranate on doxorubicin-induced toxicity in rat. Pharm Biol. 2011 Apr;49(4):377-82.

Hassing LB, Johansson B, Nilsson SE, Berg S, Pedersen NL, Gatz M, McClearn G. Diabetes mellitus is a risk factor for vascular dementia, but not for Alzheimer’s disease: a population-based study of the oldest old. Int Psychogeriatr 2002;14:239-48.

Hidaka M, Okumura M, Fujita K, Ogikubo T, Yamasaki K, Iwakiri T, Setoguchi N, Arimori K (2005): Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos;33:644–648.

Hong MY, Seeram NP, Heber D (2008): Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. J Nutr Biochem;19:848–855.

Hosseini B, Saedisomeolia A, Wood LG, Yaseri M, Tavasoli S (2016): Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: A randomized controlled clinical trial. Complement Ther Clin Pract; 22: 44-50.

Huang TH, Yang Q, Harada M, Li GQ, Yamahara J, Roufogalis BD, Li Y (2005): Pomegranate flower extract diminishes cardiac fibrosis in Zucker diabetic fatty rats: modulation of cardiac endothelin-1 and nuclear factor-kappaB pathways. J Cardiovasc Pharmacol;46:856–862.

Ignarro LJ, Byrns RE, Sumi D, de Nigris F, Napoli C (2006): Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. Nitric Oxide;15:93–102.

Irace C, Cortese C, Fiaschi E, et al. The influence of PON1 192 polymorphism on endothelial function in diabetic subjects with or without hypertension. Hypertens Res. 2008 Mar;31(3):507-13.

Jacob LM (2007): Granatapfel: Prävention und adjuvante Ernährungstherapie bei Krebserkrankungen. Erfahrungsheilkunde;56:464–473.

Jacob LM (2007): Granatapfel: Prävention und adjuvante Ernährungstherapie bei Herz-Kreislauf-Erkrankungen. Erfahrungsheilkunde;56:602–610.

Jacob LM (2008): Granatapfel als Zellregulator. Komplement Integr Med;1:16–20.

Jacob LM, Klippel KF (2008): Granatapfelpolyphenole gegen Prostatakarzinom. Dtsch Z Onkol; 40:112–119.

Jarvis S, Li C, Bogle RG (2010): Possible interaction between pomegranate juice and warfarin. Emerg Med J. Jan;27(1):74-5.

Jefcoate CR, Liehr JG, Santen RJ, Sutter TR, Yager JD, Yue W, Santner SJ, Tekmal R, Demers L, Pauley R, Naftolin F, Mor G, Berstein L (2000): Tissue-specific synthesis and oxidative metabolism of estrogens. J Natl Cancer Inst Monogr;27:95–112.

Kasimsetty SG, Bialonska D, Reddy MK, Thornton C, Willett KL, Ferreira D (2009): Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells. J Agric Food Chem;57:10636–10644.

Kawaii S, Lansky EP (2004): Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells. J Med Food;7:13–18.

Keating NL, O'Malley AJ, Freedland SJ, Smith MR (2010): Diabetes and cardiovascular disease during androgen deprivation therapy: observational study of veterans with prostate cancer. J Natl Cancer Inst. Jan 6;102(1):39-46.

Keating NL, O'Malley AJ, Smith MR (2006): Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. J Clin Oncol. Sep 20;24(27):4448-56.

Kelishadi R, Gidding SS, Hashemi M, Hashemipour M, Zakerameli A, Poursafa P. Acute and long term effects of grape and pomegranate juice consumption on endothelial dysfunction in pediatric metabolic syndrome. J Res Med Sci. 2011 Mar;16(3):245-53.

Kennedy T, Ghio AJ, Reed W, Samet J, Zagorski J, Quay J, Carter J, Dailey L, Hoidal JR, Devlin RB (1998): Copper-dependent inflammation and nuclear factor-kappaB activation by particulate air pollution. Am J Respir Cell Mol Biol;19:366–378.

Khan N, Afaq F, Kweon MH, Kim K, Mukhtar H (2007): Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res;67:3475–3482.

Khan N, Hadi N, Afaq F, Syed DN, Kweon MH, Mukhtar H (2007): Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice. Carcinogenesis;28:163–173.

Khateeb J, Gantman A, Kreitenberg AJ, Aviram M, Fuhrman B. Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-gamma pathway. Atherosclerosis. 2010 Jan;208(1):119-25.

Kim DO, Lee KW, Lee HL, Lee CY (2002): Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. J Agric Food Chem;50:3713–3717.

Kim H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH (2006): Inhibitory effects of fruit juices on CYP3A activity. Drug Metab Dispos;34:521–523.

Kim JA, Wei Y, Sowers JR (2008) Role of mitochondrial dysfunction in insulin resistance. Circ Res 102: 401–414.

Kim ND, Mehta R, Yu W, Neeman I, Livney T, Amichay A, Poirier D, Nicholls P, Kirby A, Jiang W, Mansel R, Ramachandran C, Rabi T, Kaplan B, Lansky E (2002): Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat;71:203–217.

Komperda KE (2009): Potential interaction between pomegranate juice and warfarin. Pharmacotherapy. Aug;29(8):1002-6.

Koren-Gluzer M, Aviram M, Meilin E, Hayek T. The antioxidant HDL-associated paraoxonase-1 (PON1) attenuates diabetes development and stimulates beta-cell insulin release. Atherosclerosis. 2011 Dec;219(2):510-518.

Kristal B, Shema L, Ore L, Shapiro G, Geron R, Sela S (2010): One Year of Pomegranate Juice Consumption Decrease Oxidative Stress, Inflammation and Incidence of Infections in Hemodialysis Patients. ASN; Abstract TH-FC059: 14A.

Kulkarni AP, Mahal HS, Kapoor S, Aradhya SM (2007): In vitro studies on the binding, antioxidant, and cytotoxic actions of punicalagin. J Agric Food Chem;55:1491–1500.

Lansky EP (2006): Beware of pomegranates bearing 40% ellagic acid. J Med Food;9:119–122.

Lansky EP, Harrison G, Froom P, Jiang WG (2005): Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel. Invest New Drugs;23:121–122.

Lansky EP, Jiang W, Mo H, Bravo L, Froom P, Yu W, Harris NM, Neeman I, Campbell MJ (2005): Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions. Invest New Drugs 2005;23:11–20.

Larrosa M, González-Sarrías A, García-Conesa MT, Tomás-Barberán FA, Espín JC (2006): Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities. J Agric Food Chem;54:1611–1612.

Leduc V, Poirier J. Polymorphisms at the paraoxonase 1 L55M and Q192R loci affect the pathophysiology of Alzheimer's disease: emphasis on the cholinergic system and beta-amyloid levels. Neurodegener Dis. 2008;5(3-4):225-7. Epub 2008 Mar 6.

Leduc V, Théroux L, Dea D, Robitaille Y, Poirier J. Involvement of paraoxonase 1 genetic variants in Alzheimer's disease neuropathology. Eur J Neurosci. 2009 Nov;30(9):1823-30. Epub 2009 Oct 26.

Li Z, Henning SM, Lee RP, Lu QY, Summanen PH, Thames G, Corbett K, Downes J, Tseng CH, Finegold SM, Heber D (2015a): Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers. Food Funct; 6(8): 2487-2495.

Li Z, Summanen PH, Komoriya T, Henning SM, Lee RP, Carlson E, Heber D, Finegold SM (2015b): Pomegranate ellagitannins stimulate growth of gut bacteria in vitro: Implications for prebiotic and metabolic effects. Anaerobe; 34: 164-168.

Lowndes SA, Harris AL (2005): The role of copper in tumour angiogenesis. J Mammary Gland Biol Neoplasia;10:299–310.

Lubik AA, Gunter JH, Hendy SC, Locke JA, Adomat HH, Thompson V, Herington A, Gleave ME, Pollak M, Nelson CC (2011): Insulin increases de novo steroidogenesis in prostate cancer cells. Cancer Res.; 71(17):5754-64.

Makino-Wakagi Y, Yoshimura Y, Uzawa Y, Zaima N, Moriyama T, Kawamura Y. Ellagic acid in pomegranate suppresses resistin secretion by a novel regulatory mechanism involving the degradation of intracellular resistin protein in adipocytes. Biochem Biophys Res Commun. 2012 Jan 13;417(2):880-5.

Malik A, Afaq F, Sarfaraz S, Adhami VM, Syed DN, Mukhtar H (2005): Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci U S A;102:14813–14818.

Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L (2004): Polyphenols: food sources and bioavailability. Am J Clin Nutr;79:727–747.

Martin KR, Krueger CG, Rodriquez G, Dreher M, Reed JD (2009): Development of a novel pomegranate standard and new method for the quantitative measurement of pomegranate polyphenols. Journal of the Science of Food and Agriculture, Volume 89, Number 1, 15 January, pp. 157-162(6)

Martins IJ, Hone E, Foster JK, Sünram-Lea SI, Gnjec A, Fuller SJ, Nolan D, Gandy SE, Martins RN. Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease. Mol Psychiatry. 2006 Aug;11(8):721-36. Epub 2006 Jun 20.

Mattiello T, Trifiro E, Jotti GS, Pulcinelli FM. Effects of pomegranate juice and extract polyphenols on platelet function. J Med Food. 2009 Apr;12(2):334-9.

McCall P, Gemmell LK, Mukherjee R, Bartlett JM, Edwards J (2008): Phosphorylation of the androgen receptor is associated with reduced survival in hormone-refractory prostate cancer patients. Br J Cancer;98:1094–1101.

Mikhailova M, Wang Y, Bedolla R, Lu XH, Kreisberg JI, Ghosh PM (2008): AKT regulates androgen receptor-dependent growth and PSA expression in prostate cancer. Adv Exp Med Biol;617:397–405.

Milner JA (2004): Molecular targets for bioactive food components. J Nutr;134:2492S–2498S.

Milner JA (2006): Diet and cancer: facts and controversies. Nutr Cancer;56:216–224.

Mirmiran P, Fazeli MR, Asghari G, Shafiee A, Azizi F (2010): Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial. Br J Nutr; 104(3): 402-406.

Mohan M, Patankar P, Ghadi P, Kasture S. Cardioprotective potential of Punica granatum extract in isoproterenol-induced myocardial infarction in Wistar rats. J Pharmacol Pharmacother. 2010 Jan;1(1):32-7.

Mohan M, Waghulde H, Kasture S. Effect of pomegranate juice on Angiotensin II-induced hypertension in diabetic Wistar rats. Phytother Res. 2010 Jun;24 Suppl 2:S196-203.

Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, True LD, Nelson PS (2008): Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res;68:4447–4454.

Naujokat C, Laufer S (2013): Targeting cancer stem cells with defined compounds and drugs. J Canc Res Updates; 2: 36-67.

Nayak SB, Bhat VR, Upadhyay Dinesh, Udupa SL (2003): Copper and ceruloplasmin status in serum of prostate and colon cancer patients. Indian J Physiol Pharmacol;47:108–110.

Nonomura N, Nakayama M, Takayama H, Nishimura K, Okuyama A (2008): [Molecular-targeted therapy for prostate cancer]. Hinyokika Kiyo;54:63–66.

Núñez-Sánchez MÁ, Karmokar A, González-Sarrías A, García-Villalba R, Tomás-Barberán FA, García-Conesa MT, Brown K, Espín JC (2016): In vivo relevant mixed urolithins and ellagic acid inhibit phenotypic and molecular colon cancer stem cell features: A new potentiality for ellagitannin metabolites against cancer. Food Chem Toxicol; 92: 8-16.

Olsen SR (2005): Taxanes and COX-2 inhibitors: from molecular pathways to clinical practice. Biomed Pharmacother;59:306–310.

Paller CJ, Ye X, Wozniak PJ, Gillespie BK, Sieber PR, Greengold RH, Stockton BR, Hertzman BL, Efros MD, Roper RP, Liker HR, Carducci MA (2012): A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. Prostate Cancer Prostatic Dis. 2012 Jun 12.

Panchal SK, Ward L, Brown L. Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. Eur J Nutr. 2012 Apr 27.

Pantuck AJ, Leppert JT, Zomorodian N, Aronson W, Hong J, Barnard RJ, Seeram N, Liker H, Wang H, Elashoff R, Heber D, Aviram M, Ignarro L, Belldegrun A (2006): Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res;12:4018–4026.

Pantuck AJ, Zomorodian Z, Rettig M, Aronson WJ, Heber D, Belldegrun AS (2009) Long term follow up of phase 2 study of pomegranate juice for men with prostate cancer shows durable prolongation of PSA doubling time. J Urol; 181(4 Suppl): 295.

Papoutsi Z, Kassi E, Tsiapara A, Fokialakis N, Chrousos GP, Moutsatsou P (2005): Evaluation of estrogenic/antiestrogenic activity of ellagic acid via the estrogen receptor subtypes ERalpha and ERbeta. J Agric Food Chem;53:7715–7720.

Pasqualini L, Cortese C, Marchesi S, et al. Paraoxonase-1 activity modulates endothelial function in patients with peripheral arterial disease. Atherosclerosis. 2005 Dec;183(2):349-54.

Pelucchi C, Serraino D, Negri E, Montella M, Dellanoce C, Talamini R, La Vecchia C (2011): The metabolic syndrome and risk of prostate cancer in Italy. Ann Epidemiol. 2011 Nov;21(11):835-41.

Platz EA, Leitzmann MF, Visvanathan K, Rimm EB, Stampfer MJ, Willett WC, Giovannucci E (2006): Statin drugs and risk of advanced prostate cancer. J Natl Cancer Inst;98:1819–1825.

Regieli JJ, Jukema JW, Doevendans PA, et al. Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention. J Am Coll Cardiol. 2009 Sep 29;54(14):1238-45.

Rettig MB, Heber D, An J, Seeram NP, Rao JY, Liu H, Klatte T, Belldegrun A, Moro A, Henning SM, Mo D, Aronson WJ, Pantuck A (2008): Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism. Mol Cancer Ther;7:2662–2671.

Rosenblat M, Aviram M. Paraoxonases role in the prevention of cardiovascular diseases. Biofactors. 2009 Jan-Feb;35(1):98-104.

Rosenblat M, Aviram M. Pomegranate juice protects macrophages from Triglyzeride accumulation: inhibitory effect on DGAT1 activity and on Triglyzeride biosynthesis. Ann Nutr Metab. 2011;58(1):1-9.

Rosenblat M, Hayek T, Aviram M (2006): Antioxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis;187:363–371.

Rosenblat M, Volkova N, Attias J, Mahamid R, Aviram M. Consumption of polyphenolic-rich beverages (mostly pomegranate and black currant juices) by healthy subjects for a short term increased serum antioxidant status, and the serum’s ability to attenuate macrophage cholesterol accumulation. Food Funct. 2010 Oct;1(1):99-109.

Rosenblat M, Volkova N, Aviram M. Pomegranate juice (PJ) consumption antioxidative properties on mouse macrophages, but not PJ beneficial effects on macrophage cholesterol and Triglyzeride metabolism, are mediated via PJ-induced stimulation of macrophage PON2. Atherosclerosis. 2010 Sep;212(1):86-92.

Rosenblat M, Volkova N, Ward J, Aviram M. Paraoxonase 1 (PON1) inhibits monocyte-to-macrophage differentiation. Atherosclerosis. 2011 Nov;219(1):49-56.

Sartippour MR, Seeram NP, Rao JY, Moro A, Harris DM, Henning SM, Firouzi A, Rettig MB, Aronson WJ, Pantuck AJ, Heber D (2008): Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo. Int J Oncol;32:475–480.

Schubert SY, Neeman I, Resnick N: A novel mechanism for the inhibition of NF-kappaB activation in vascular endothelial cells by natural antioxidants. FASEB J 2002;16:1931–1933.

Seeram NP, Aronson WJ, Zhang Y, Henning SM, Moro A, Lee RP, Sartippour M, Harris DM, Rettig M, Suchard MA, Pantuck AJ, Belldegrun A, Heber D (2007): Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. J Agric Food Chem;55:7732–7737.

Seeram NP, Henning SM, Zhang Y, Suchard M, Li Z, Heber D (2006): Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. J Nutr;136:2481–2485.

Shema-Didi L, Sela S, Ore L, Shapiro G, Geron R, Moshe G, Kristal B. One Year of Pomegranate Juice Intake Decreases Oxidative Stress, Inflammation and Incidence of Infections in Hemodialysis Patients: A randomized Placebo-controlled trial. Free Radic Biol Med. 2012 May 17.

Shimogaki H, Tanaka Y, Tamai H, Masuda M (2000): In vitro and in vivo evaluation of ellagic acid on melanogenesis inhibition. Int J Cosmet Sci;22:291–303.

Shiner M, Fuhrman B, Aviram M. Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR gamma and AP-1 pathway activation. Atherosclerosis. 2007 Dec;195(2):313-21. Epub 2007 Feb 12.

Shukla M, Gupta K, Rasheed Z, Khan KA, Haqqi TM (2008): Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro. J Inflamm (Lond);5:9.

Soran H, Younis NN, Charlton-Menys V, Durrington P. Variation in paraoxonase-1 activity and atherosclerosis. Curr Opin Lipidol. 2009 Aug;20(4):265-74.

Sorokin AV, Duncan B, Panetta R, Thompson PD (2006): Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol;98:705–706.

Sumner MD, Elliott-Eller M, Weidner G, Daubenmier JJ, Chew MH, Marlin R, Raisin CJ, Ornish D (2005): Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease. Am J Cardiol;96:810–814.

Syed DN, Malik A, Hadi N, Sarfaraz S, Afaq F, Mukhtar H (2006): Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermal keratinocytes. Photochem Photobiol;82:398–405.

Thomas R, Williams M, Sharma H, Chaudry A, Bellamy P (2013): The polyphenol rich whole food supplement Pomi-T® proven to have a direct anti-cancer effect in men with prostate cancer. J Clin Oncol; 31 (Suppl; abs 5008).

Toi M, Bando H, Ramachandran C, Melnick SJ, Imai A, Fife RS, Carr RE, Oikawa T, Lansky EP (2003): Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo. Angiogenesis;6:121–128.

Toklu HZ, Dumlu MU, Sehirli O, Ercan F, Gedik N, Gökmen V, Sener G. Pomegranate peel extract prevents liver fibrosis in biliary-obstructed rats. J Pharm Pharmacol. 2007 Sep;59(9):1287-95.

Tomás-Barberán FA, González-Sarrías A, García-Villalba R, Núñez-Sánchez MA, Selma MV, García-Conesa MT, Espín JC (2016): Urolithins, the rescue of 'old' metabolites to understand a 'new' concept: metabotypes as a nexus between phenolic metabolism, microbiota dysbiosis and host health status. Mol Nutr Food Res; [Epub ahead of print].

Trombold JR, Barnes JN, Critchley L, Coyle EF (2010): Ellagitannin consumption improves strength recovery 2-3 d after eccentric exercise. Med Sci Sports Exerc; 42(3): 493-498.

Türk G, Sönmez M, Aydin M, Yüce A, Gür S, Yüksel M, Aksu EH, Aksoy H. Effects of pomegranate juice consumption on sperm quality, spermatogenic cell density, antioxidant activity and testosterone level in male rats. Clin Nutr. 2008 Apr;27(2):289-96.

Tvarijonaviciute A, Kocaturk M, Cansev M, Tecles F, Ceron JJ, Yilmaz Z. Serum butyrylcholinesterase and paraoxonase 1 in a canine model of endotoxemia: Effects of choline administration. Res Vet Sci. 2011 Oct 12.

Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M (2006): Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact;160:1–40.

van Himbergen TM, van Tits LJ, Hectors MP, de Graaf J, Roest M, Stalenhoef AF. Paraoxonase-1 and linoleic acid oxidation in familial hypercholesterolemia. Biochem Biophys Res Commun. 2005 Aug 5;333(3):787-93.

Varatharajalu R, Garige M, Leckey LC, Gong M, Lakshman MR. Betaine protects chronic alcohol and omega-3 PUFA-mediated down-regulations of PON1 gene, serum PON1 and homocysteine thiolactonase activities with restoration of liver GSH. Alcohol Clin Exp Res. 2010 Mar 1;34(3):424-31. Epub 2009 Dec 17.

Vial G, Dubouchaud H, Leverve XM (2010): Liver mitochondria and insulin resistance. Acta Biochim Pol. 2010;57(4):389-92.

Wu TJ, Sempos CT, Freudenheim JL, Muti P, Smith E (2004): Serum iron, copper and zinc concentrations and risk of cancer mortality in US adults. Ann Epidemiol;14:195–201.

Yang J, Lee R, Henning SM, Thames G, Hsu M, ManLam H, Heber D, Li Z (2016): Soy protein isolate does not affect ellagitannin bioavailability and urolithin formation when mixed with pomegranate juice in humans. Food Chem; 194: 1300-1303.

Yildiz A, Sezen Y, Gur M, Yilmaz R, Demirbag R, Erel O. Association of paraoxonase activity and coronary collateral flow. Coron Artery Dis. 2008 Nov;19(7):441-7.

Yki-Järvinen H. Liver fat in the pathogenesis of insulin resistance and type 2 diabetes. Dig Dis. 2010;28(1):203-9. Epub 2010 May 7.


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